The study on metabolic difference of human body affected by active stress and passive stress under special events / 南方医科大学学报

<p><b>OBJECTIVE</b>To study the metabolic difference of body influenced by active stress and passive stress under special events.</p><p><b>METHODS</b>To detect serum multiple biochemistry index of 57 earthquake rescue medical team and 13 victims of a natural calamity in Wenchuan earthquake by using Hitachi 7600 automatic analyzer.</p><p><b>RESULTS</b>Stress affected biochemistry index deeply. To compared with rescue medical team, the serum ADA, ALP and TG of victims increased obviously and TP, ALB, MAO, Cr, UA, K, Na, Cl, Ca, ApoA1 and HDL decreased obviously.</p><p><b>CONCLUSION</b>Many biochemistry index have been changed under stress and it relate with stress extent. The human body function status was better in active stress than in passive stress.</p>

Change of IL-4 and IL-6 levels in blood plasma of patients transplanted with allogeneic hematopoietic stem cells determined by protein chip and its relationship with aGVHD / 中国实验血液学杂志

This study was aimed to explore the relationship between changes of IL-4, IL-6 levels in blood plasma of patients receiving allo-HSCT and aGVHD through dynamical detection. The IL-4 and IL-6 levels in peripheral blood were detected by protein chip and were observed for 10 weeks. The results indicated that the IL-4 level increased rapidly in 1 week after transplantation in aGVHD group and was higher than that of non aGVHD group (p<0.05), while at 7th week after transplantation IL-4 level increased rapidly in non-GVHD group and was higher than that of aGVHD group (p<0.01). There was a significant difference of IL-6 level between these two groups before transplantation. IL-6 level reached peak at 1st week after transplantation in aGVHD group and was higher than that of non-aGVHD group (p<0.01), while IL-6 level was significantly higher in non-aGVHD group than that of aGVHD group at 4th week after transplantation (p<0.01) and at 5th week after transplantation (p<0.05). It is concluded that the levels of IL-4 and IL-6 had been increased rapidly after hematopoietic stem cell transplantation, indicating that aGVHD will occur. The high level of IL-6 before transplantation may be the risk factor of aGVHD occurrence after transplantation. aGVHD may occur later if the blood plasma IL-4 level rises in patients without aGVHD. Therefore, dynamically monitoring IL-4 and IL-6 levels contributes to predict the occurrence of aGVHD.

Studies on twelve cytokines in serum of coronary heart disease patients / 中华检验医学杂志

Objective The significance of serum cytokine profile in coronary heart disease patients have been evaluated by observing the variation cytokines Methods The serum IL-1 a,IL-1 ?,IL-2,IL-4, IL-6 ,IL-8,IL-10,VEGF,IFN-?,,TNF-?,MCP-1 and EGF in 76 patients and 26 matched healthy volunteers have been observed.Serum cytokines had been measured by protein chips methods in EVIDENCE 180 automatic biochips analyzer and cytokine profile were got by bioinformatics.Results The serum level of IL-1?,IL-6,IL-8,and TNF-? were (4.32?8.14) ng/L ,(13.16?16.81) rig/L,(375.53?292.14) ng/L,(15.46?15.38) ng/L respectively,which increased obviously in patients (P